Mesothelioma Symptoms and Signs : The search for new treatments or strategies is therefore crucial and the inclusion of patients in clinical trials is strongly encouraged. STATE OF KNOWLEDGE Among the treatments evaluated, various immunotherapies, in particular immune checkpoint inhibitors (ICI) have shown promising preliminary results. The first results of the phase II randomized trial, IFCT-MAPS-2, recently confirmed the benefit of ICI in MPM in the event of chemotherapy failure. Mesothelioma Symptoms and Signs
🔺🔻 Mesothelioma Symptoms and Signs Perspectives and Conclusions However, many more exciting immunotherapies are being evaluated and presented here. 💠
Questions are still unresolved: their place in the first line, the targeting of patients, the combinations between them and / or with targeted therapies, chemotherapy. Finally, it is essential that any clinician has sufficient knowledge of the toxicities of immunotherapies. Mesothelioma Symptoms and Signs
Introduction Malignant pleural mesothelioma (MPM) is a quite rare cancer, but with increasing incidence, that is usually induced by previous asbestos exposure. Surgery of MPM, done only by few expert teams within a multimodal treatment is of limited and still disputed value. The standard treatment of MPM, relying on first-line chemotherapy by combined cisplatin-pemetrexed is often poorly effective, even if combination with bevacizumab anti-VEGF antibodies has slightly improved the results. Moreover, no second line treatment is recommended in case of failure of this chemotherapy. Therefore, the search of new therapies or strategies is crucial and the recruitment of patients in clinical trials is highly encouraged.
Background Among the treatments under investigation, various anti-tumor immunotherapies, in particular immune checkpoints inhibitors (ICI), currently exhibit the most promising preliminary results. First data from the phase II, randomized “IFCT MAPS-2”, recently presented during the 2017 ASCO meeting, confirmed the value of ICI in MPM patients in cases of chemotherapy failure. Outlook and conclusions However, several exciting immunotherapies other than ICI are presently being evaluated in MPM and are reported in this article. Moreover, many questions still need to be answered about immunotherapy: what is its potential value as first line treatment? How to target the best candidates for these treatments? Which combinations between immunotherapy and standard chemotherapy, targeted therapies, surgery or radiotherapy? Finally,
🔲 Mesothelioma Symptoms and Signs Stages of pleural mesothelioma 🔳
Staging describes or classifies cancer based on how much cancer is in the body and where it was when initially diagnosed. This is often referred to as the extent of cancer. Information from tests is used to find out how big the tumor is, which parts of the organ have cancer, whether the cancer has spread from where it started, and where it has spread. Your healthcare team uses the stage to plan your treatment and predict the outcome (your prognosis).
⚪ Mesothelioma Symptoms and Signs Pleural mesothelioma starts in the lining (membrane) that forms a protective cushion around the lungs (called a pleura). ⚫
The most frequently used staging system for pleural mesothelioma is the TNM classification. In the case of this type of cancer, there are 4 stages. For stages 1 to 4, we often use the Roman numerals I, II, III and IV, but, in order to make the text clearer, we will use the Arabic numerals 1, 2, 3 and 4. In general, more the higher the stage number, the more cancer has spread. Talk to your doctor if you have any questions about staging.
The TNM classification is used to establish the stage of pleural mesothelioma only. There is no staging system for mesothelioma that appears in the lining of the abdomen (peritoneal mesothelioma) or for rare types of mesothelioma.
Find out more about cancer staging .